Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer
Hoodie Background Anti-PD-1(L1) therapies are less efficacious in patients with EGFR-mutated non-small-cell lung cancer.However, the underlying mechanism is poorly understood.Methods The characteristics of T cells in EGFR-mutated and wild-type tumors were analyzed based on The Cancer Genome Atlas database and clinical samples.Plasma levels of 8 T-c