INTERLEUKIN-10 INDUCES EXPRESSION OF CD39 ON CD8+T CELLS TO POTENTIATE ANTI-PD1 EFFICACY IN EGFR-MUTATED NON-SMALL CELL LUNG CANCER

Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer

Hoodie Background Anti-PD-1(L1) therapies are less efficacious in patients with EGFR-mutated non-small-cell lung cancer.However, the underlying mechanism is poorly understood.Methods The characteristics of T cells in EGFR-mutated and wild-type tumors were analyzed based on The Cancer Genome Atlas database and clinical samples.Plasma levels of 8 T-c

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Region selection and efficiency improvement for apple production using an indicator system based on cost-effective factors

Balanced and coordinated allocation of production factors is crucial for promoting the apple industry.We constructed a cost-ecological 21-indicator system for apple production in China based on labour cost, opportunity cost, fertilizer machinery input, natural resource, meteorological factor, ecological pressure and topography.The Hurst Index was u

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Investigating the Portability Bacteria Proteus mirabilis Isolated From Wounds and Burns Infections to Form Swarming and Study the Virulence Factor Genetically.

This study was designed to investigate ability of the bacteria Proteus mirabilis isolated from wounds and burns infections to production of virulence factor swarming and samples elected included the most antibiotic-resistant isolates and by (4) HEADBANDS isolates of the bacterium Proteus mirabilis diagnosed depending on the biochemical test as well

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Smart Crop Cultivation System Using Automated Agriculture Monitoring Environment in the Context of Bangladesh Agriculture

The Internet of Things (IoT) is a transformative technology that is reshaping industries and daily life, leading us towards a connected future that is full of possibilities and innovations.In this paper, we present a robust framework for the application of Internet of Things (IoT) Hoodie technology in the agricultural sector in Bangladesh.The frame

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A revision of the Afrotropical hover fly genus Afroxanthandrus Kassebeer, 2000 (Diptera, Syrphidae), with the description of two new species and one new synonymy

The hover fly (Diptera: Syrphidae) genus Afroxanthandrus Kassebeer, 2000 is revised based on morphological and molecular characters.Two new species, Afroxanthandrus comorosensis sp.nov., and Afroxanthandrus conopeum sp.nov.are described, Natural Feminine while Xanthandrus magnificus Thompson, 2019 is a new junior synonym of Afroxanthandrus congensi

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